Pharmacokinetic implications of stereoselective changes in plasma-protein binding: Warfarin/sulfinpyrazoneTOON, S; TRAGER, W. F.Journal of pharmaceutical sciences. 1984, Vol 73, Num 11, pp 1671-1673, issn 0022-3549Article

Prochiral selectivity and intramolecular isotope effects in the cytochrome P-450 catalyzed ω-hydroxylation of cumeneSUGIYAMA, K; TRAGER, W. F.Biochemistry (Easton). 1986, Vol 25, Num 23, pp 7336-7343, issn 0006-2960Article

High-yield synthesis of warfarin and its phenolic metabolites: new compoundsBUSH, E; TRAGER, W. F.Journal of pharmaceutical sciences. 1983, Vol 72, Num 7, pp 830-831, issn 0022-3549Article

Stereochemical considerations in drug metabolismTRAGER, W. F; JONES, J. P.Progress in drug metabolism. 1987, Vol 10, pp 55-83, issn 0364-8974Article

Warfarin-fluconazole III : A rationale approach to management of a metabolically based drug interactionKUNZE, K. L; TRAGER, W. F.Drug metabolism and disposition. 1996, Vol 24, Num 4, pp 429-435, issn 0090-9556Article

Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafyllineKUNZE, K. L; TRAGER, W. F.Chemical research in toxicology. 1993, Vol 6, Num 5, pp 649-656, issn 0893-228XArticle

Substrate probes for the mechanism of aromatic hydroxylation catalyzed by cytochrome P-450: selectively deuterated analogues of warfarinBUSH, E. D; TRAGER, W. F.Journal of medicinal chemistry (Print). 1985, Vol 28, Num 8, pp 992-996, issn 0022-2623Article

The use of Brauman's least squares approach for the quantification of deuterated chlorophenolsKORZEKWA, K; HOWALD, W. N; TRAGER, W. F et al.Biomedical & environmental mass spectrometry. 1990, Vol 19, Num 4, pp 211-217, issn 0887-6134, 7 p.Article

Stereoselective metabolism of conformational analogues of warfarin by β-naphthoflavone-inducible cytochrome P-450HEIMARK, L. D; TRAGER, W. F.Journal of medicinal chemistry (Print). 1985, Vol 28, Num 4, pp 503-506, issn 0022-2623Article

The preferred solution conformation of warfarin at the active site of cytochrome P-450 based on the CD spectra in octanol water model systemHEIMARK, L. D; TRAGER, W. F.Journal of medicinal chemistry (Print). 1984, Vol 27, Num 8, pp 1092-1095, issn 0022-2623Article

Inhibition of (S)-warfarin metabolism by sulfinpyrazone and its metabolitesMINXIA HE; KUNZE, K. L; TRAGER, W. F et al.Drug metabolism and disposition. 1995, Vol 23, Num 6, pp 659-663, issn 0090-9556Article

The separation of the intramolecular isotope effect for the cytochrome P-450 catalyzed hydroxylation of n-octane into its primary and secondary componentsJONES, J. P; TRAGER, W. F.Journal of the American Chemical Society. 1987, Vol 109, Num 7, pp 2171-2173, issn 0002-7863Article

A stable isotope assay for phenprocoumon and its metabolitesHEIMARK, L. D; TRAGER, W. F.Biomedical mass spectrometry. 1985, Vol 12, Num 2, pp 67-71, issn 0306-042XArticle

Intrinsic isotope effects suggest that the reaction coordinate symmetry for the cytochrome P-450 catalyzed hydroxylation of octane is isozyme independentJONES, J. P; RETTIE, A. E; TRAGER, W. F et al.Journal of medicinal chemistry (Print). 1990, Vol 33, Num 4, pp 1242-1246, issn 0022-2623, 5 p.Article

Isotopically labeled chlorobenzenes as probes for the mechanism of cytochrome P-450 catalyzed aromatic hydroxylationKORZEKWA, K. R; SWINNEY, D. C; TRAGER, W. F et al.Biochemistry (Easton). 1989, Vol 28, Num 23, pp 9019-9027, issn 0006-2960Article

The binding and regioselectivity of reaction of (R)- and (S)-nicotine with cytochrome P-450cam : parallel experimental and theoretical studiesJONES, J. P; TRAGER, W. F; CARLSON, T. J et al.Journal of the American Chemical Society. 1993, Vol 115, Num 2, pp 381-387, issn 0002-7863Article

Theory for the observed isotope effects from enzymatic systems that form multiple products via branched reaction pathways: cytochrome P-450KORZEKWA, K. R; TRAGER, W. F; GILLETTE, J. R et al.Biochemistry (Easton). 1989, Vol 28, Num 23, pp 9012-9018, issn 0006-2960Article

Influence of stiripentol on cytochrome P450-mediated metabolic pathways in humans : In vitro and in vivo comparison and calculation of in vivo inhibition constantsTRAN, A; KEY, E; TRAGER, W. F et al.Clinical pharmacology and therapeutics. 1997, Vol 62, Num 5, pp 490-504, issn 0009-9236Article

Formation of (R)-8-hydroxywarfarin in human liver microsomes : A new metabolic marker for the (S)-mephenytoin hydroxylase, P4502C19WIENKERS, L. C; WURDEN, C. J; STORCH, E et al.Drug metabolism and disposition. 1996, Vol 24, Num 5, pp 610-614, issn 0090-9556Article

Application of negative-ion chemical ionization isotope dilution gas chromatography-mass spectrometry to single-dose bioavailability studies of mefloquineNEAL, J. M; HOWALD, W. N; KUNZE, K. L et al.Journal of chromatography. B, Biomedical applications. 1994, Vol 661, Num 2, pp 263-269Article

Theoretical studies on the mechanism of conversion of androgens to estrogens by aromataseKORZEKWA, K. R; TRAGER, W. F; SMITH, S. J et al.Biochemistry (Easton). 1991, Vol 30, Num 25, pp 6155-6162, issn 0006-2960Article

A refined 3-dimensional QSAR of cytochrome P450 2C9: Computational predictions of drug interactionsRAO, S; AOYAMA, R; SCHRAG, M et al.Journal of medicinal chemistry (Print). 2000, Vol 43, Num 15, pp 2789-2796, issn 0022-2623Article

Three-dimensional quantitative structure-activity relationship for inhibitors of cytochrome P4502C9JONES, J. P; MINXIA HE; TRAGER, W. F et al.Drug metabolism and disposition. 1996, Vol 24, Num 1, pp 1-6, issn 0090-9556Article

Isotope effect studies on the cytochrome P450 enzymesKORZEKWA, K. R; GILLETTE, J. R; TRAGER, W. F et al.Drug metabolism reviews (Softcover ed.). 1995, Vol 27, Num 1-2, pp 45-59, issn 0360-2532Conference Paper

Disposition of drugs in cystic fibrosis. VI: In vitro activity of cytochrome P450 isoforms involved in the metabolism of (R)-warfarin (including P450 3A4) is not enhanced in cystic fibrosisJI-PING WANG; UNADKAT, J. D; MCNAMARA, S et al.Clinical pharmacology and therapeutics. 1994, Vol 55, Num 5, pp 528-534, issn 0009-9236Article